prefrontal cortex

noun

: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning

Examples of prefrontal cortex in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
The dorsolateral prefrontal cortex monitors uncertainty and flags when expectations or norms get broken. — Yigit Topoglu, The Conversation, 3 Aug. 2026 Days later, a dental scan for a toothache found a four-inch nail embedded near his prefrontal cortex. — Kevin Kruse, Forbes.com, 31 July 2026 My prefrontal cortex, for better or worse, developed during my Phish era. — Claire Howorth, Vanity Fair, 29 July 2026 Your brain activity shifts away from the regions that drive emotional reactivity and toward the prefrontal cortex, which is responsible for logical thinking. — Amy Morin, CNBC, 21 June 2026 See All Example Sentences for prefrontal cortex

Word History

First Known Use

1892, in the meaning defined above

Time Traveler
The first known use of prefrontal cortex was in 1892

Rhymes for prefrontal cortex

See All Rhymes for prefrontal cortex

Browse Nearby Words

prefrontal
prefrontal cortex
prefrozen
See all Nearby Words

Cite this Entry

“Prefrontal cortex.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/prefrontal%20cortex. Accessed 13 Aug. 2026.

Copy Citation

Medical Definition

prefrontal cortex

noun
: the gray matter of the anterior part of the frontal lobe that is highly developed in humans and plays a role in the regulation of complex cognitive, emotional, and behavioral functioning
Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

More from Merriam-Webster

Word of the Day

Listen to the pronunciation of salvo

See Definitions and Examples »

Popular in Grammar & Usage

See More

A Who’s Who Regarding ‘Who’s’ and ‘Whose’

7 Pairs of Commonly Confused Words

Is that lie 'bald-faced' or 'bold-faced'?

'A' or 'an'? What about before 'h'? An Indefinite Article Guide

Why is '-ed' sometimes pronounced at the end of a word?
See More

Popular in Wordplay

See More

Words from the 'Odyssey'

The Longest Long Words List

It's a Scorcher! Words for the Summer Heat

The Words of the Week - Aug. 14

12 Lovely and Unusual Words for the Natural World
See More

Popular

See More

A Who’s Who Regarding ‘Who’s’ and ‘Whose’

Words from the 'Odyssey'

The Longest Long Words List
See More

Games & Quizzes

See All
Play Quordle: Guess all four words in a limited number of tries. Each of your guesses must be a real 5-letter word.
Quordle Can you solve 4 words at once?
Play Blossom: Solve today's spelling word game by finding as many words as you can using just 7 letters. Longer words score more points.
Blossom Pick the best words!
Play Missing Letter: a crossword with a twist. Each of the 25 puzzle words start with a different letter of the alphabet. Which letter is missing?
The Missing Letter A daily crossword with a twist
fridge-magnet-letters
Drop a Letter Quiz August 2026 Drop a letter from a word to make a totally diffe...
See All